Search results for "Proteins metabolism"
showing 8 items of 8 documents
A supramolecular system that strictly follows the binding mechanism of conformational selection
2020
Induced fit and conformational selection are two dominant binding mechanisms in biology. Although induced fit has been widely accepted by supramolecular chemists, conformational selection is rarely studied with synthetic systems. In the present research, we report a macrocyclic host whose binding mechanism is unambiguously assigned to conformational selection. The kinetic and thermodynamic aspects of this system are studied in great detail. It reveals that the kinetic equation commonly used for conformational selection is strictly followed here. In addition, two mathematical models are developed to determine the association constants of the same guest to the two host conformations. A “confo…
Response to "Is the Reg3α (HIP/PAP) Protein Really an Obesogenic Factor?"
2015
Peer Reviewed
Incorporation of S35-Methionine in the microsomes and soluble proteins during the early development of the sea urchin egg
1960
Nelle uova diParacentrotus lividus gia pochi minuti dopo la fecondazione si inizia una attiva incorporazione di metionina-S35 nei microsomi e nelle proteine solubili. Si avanza l'ipotesi che cio possa indicare l'iniziarsi molto precoce della sintesi di una o piu proteine.
Simulations and Experiments in Protein Folding
2014
The interplay between simulations and experiments of protein folding has largely contributed to the elucidation of many important aspects of the phenomenon. In this chapter, I briefly describe the experiments which provide information on the kinetics of the protein folding process, and help to characterize the folding transition state. Then, I show how to probe the kinetics of protein folding using molecular dynamics simulations, how to compare the simulations with the experiments and how to help and rationalize the latter, ultimately offering a molecular picture of the process. After the production of suitable molecular dynamics simulation data in the form of trajectories, the procedure in…
Rôle of the nucleus in the maintenance of the protein level in the algaAcetabularia mediterranea
1954
Sono state studiate le variazioni del rapporto tra l'N proteico e non proteico in segmenti rigeneranti, nucleati ed anucleati, diAcetabul. medit. I risultati ottenuti hanno dimostrato che il predetto rapporto aumenta in entrambi i segmenti il primo giorno dopo l'operazione. Nei giorni seguenti esso diminuisce in entrambi i segmenti, ma piu sensibilmente in quelli anucleati, nei quali va al di sotto del valore medio delle alghe normali gia dopo il 3°–4° giorno.
Der Einfluss aliment�rer Acidosen und Alkalosen auf die Wachstumsgeschwindigkeit und die Eiweissausnutzung der Ratte
1958
Die Erzeugung einer alimentaren Acidose mit 200 mAq NH4Cl/kg Futter bei wachsenden Ratten fuhrt bei Mannchen und Weibchen zu einer schlechteren Protein-Efficiency, aber nur bei den Mannchen zu einer geringeren Wachstumsgeschwindigkeit. Eine mit NaHCO3 in analoger Weise induzierte alimentare Alkalose hat weder bei den Mannchen noch bei den Weibchen einen sicheren Einflus auf die Protein-Efficiency und auf die Wachstumsgeschwindigkeit.
Selenoprotein synthesis and side-effects of statins.
2004
Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated that the mechanism lay in a well established, but often overlooked, biochemical pathway--the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects a…
Trypsin sensitivity of some proteins of the sea-urchin egg before and after fertilization an electrophoretic analysis
1955
La frazione precipitata al 50% di saturazione di solfato di Ammonio da estratti di uova vergini e fecondate diArbacia lixula presenta all'analisi elettroforetica un gruppo principale di tre componenti. Per trattamento con tripsina questo gruppo si risolve in cinque componenti nella frazione proveniente da uova vergini ed in quattro in quella proveniente da uova fecondate.